CRISPR gene editing in human embryos wreaks chromosomal mayhem

Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing.


  • Combining thermal scanning-probe lithography with templating enables the production of high-quality gratings that manipulate light through Fourier-spectrum engineering in ways that are not achievable with conventional gratings.

    • Nolan Lassaline
    • Raphael Brechbühler
    • David J. Norris
  • Analysis of blood-derived DNA from participants in the UK Biobank demonstrates that clonal expansions of acquired copy-neutral loss of heterozygosity mutations act on inherited alleles along a chromosome arm by modifying their allelic dosages.

    • Po-Ru Loh
    • Giulio Genovese
    • Steven A. McCarroll
  • Population-specific patterns of genomic mutations and selection of haematopoietic clones in Japanese and European participants predict the divergent rates of chronic lymphocytic leukaemia and T cell leukaemia in these populations.

    • Chikashi Terao
    • Akari Suzuki
    • Yoichiro Kamatani
  • Thin films of amorphous boron nitride are mechanically and electrically robust, prevent diffusion of metal atoms into semiconductors and have ultralow dielectric constants that exceed current recommendations for high-performance electronics.

    • Seokmo Hong
    • Chang-Seok Lee
    • Hyeon Suk Shin

Extracellular RNA

RNA — the molecule best known for its part in translating genetic code into protein-making instructions — is finding a new role in medicine.
Nature Outlook